Infrastructure of Sarani Bio-Integra

Sarani Bio-Integra's infrastructure is cutting-edge, seamlessly integrating its preclinical laboratory with the esteemed Department of Molecular Medicine at St. John's Medical College Research Institute, Bangalore. This collaborative synergy fuels groundbreaking research at the intersection of biological sciences and medicine. Likewise, Sarani Bio-Integra has forged strategic partnerships with a variety of specialized professional laboratories for pivotal clinical research projects. These collaborations amplify the institute's capacity to deliver innovative and impactful studies, pushing the boundaries of scientific exploration and medical advancement.

St. John’s Medical Research Institute Collaborations

National Collaborations

All India Institute of Medical Sciences, New Delhi
All India Institute of Medical Sciences, Bhopal
Postgraduate Institute of Medical Education and Research, Chandigarh
Indian Institute of Management, Bangalore
Indian Institute of Science, Bangalore
Christian Medical College, Vellore
George Institute for Global Health, New Delhi
Biotechnology Industry Research Assistance Council (BIRAC)
University of Mysore, Karnataka
Institute of Home Economics, University of Delhi, New Delhi
Indian Institute of Technology, Madras
K.E.M Hospital, Pune
National Institute of Nutrition, Hyderabad
Manipal Academy of Higher Education, Manipal
University of Calcutta, Kolkata
National Centre for Biological Sciences, Bangalore
C-CAMP, Bangalore
Emmaus Swiss Referral and Leprosy Project (ESRHLP)
National Institute of Mental Health and Neurosciences, Bangalore
Christ University, Bangalore
Shankara Cancer Hospital, Bangalore
Wellcome DBT Indian Alliance
Translational Health Science and Technology Institute, Faridabad
Society for Applied Studies, New Delhi
National Centre for Disease Informatics and Research, Bangalore
SKAN Research Trust, Bangalore
Public Health Foundation of India, New Delhi
Seetharam Bhartia Institute of Science & Research, New Delhi

International Collaborations

Harvard T.H. Chan School of Public Health, Boston, USA
Beth Israel Deaconess Medical Centre, Harvard University, USA
University of California, San Francisco, USA
University of California, Davis, USA
University of California Global Health Institute, USA
University of Iowa, USA
University of Pittsburg, USA
Cornell University, USA
New York Academy of Sciences, USA
The George Washington University, Washington, USA
McMaster University, Hamilton, Canada
Public Health Research Institute, Canada
Child Health Foundation, USA
World Health Organization, Geneva
King’s College, London, UK
Queen Mary University of London, UK
London School of Tropical Medicine and Hygiene, UK
Swansea University, UK
Cranfield University, UK
City University, London, UK
Imperial College, London, UK
Oxford University, UK
Medical Research Council, UK
Maastricht, University, Netherlands
International Atomic Energy Agency, Vienna
International Brain Research Organization, France
ETH, Zurich, Switzerland
Fernfachhochschule Schweiz (FFHS) Switzerland
Africa Healthcare Network, Kenya, Africa
The University of the West Indies, Jamaica

The preclinical lab of Sarani Bio-Integra is in collaboration with the Department of Molecular Medicine, St. John’s Research Institute, Bangalore.

Brief introduction to the facilities:

St. John’s Research Institute (SJRI) is an integral part of the St. John’s Academy of Health Sciences that is administered by the Catholic Bishops Conference of India (CBCI) and was started in year 2004. Vision of the institute is to improve health of the community through research and development of a center for excellence in Medical Research. Division of Molecular medicine within SJRI comprises of the Cell biology, Molecular Biology Research group, Genetics, Clinical Proteomics and Oncology.

We have established a state-of-the-art molecular diagnostics lab with a full range of molecular platforms including Next-Gen-Sequencing, Real time PCR, Molecular pathology, Tissue culture and flow cytometry. The institute also has a world class biorepository with liquid N2 storage facility for clinical samples that is monitored round the clock. SJRI has a fully equipped Animal house with permits to work on small animals and registered under CPCSEA.In addition to the patient specimen centric work we have established experimental mammalian cell culture facilities and individually-ventilated –caging-systems to establish patient derived Xenografts (PDX). Using these approaches we have explored mechanisms of chemo resistance and metastasis mediated via tumor stroma interaction.

In the proteomics division, the major biophysical techniques used include absorption and emission spectroscopy and mass spectrometry. Clinically important biomarkers can be screened in the biological fluid, using mass spectrometry based proteomics. Cell culture group is interested in probing the basic biology of various biomolecules using the tissue culture facility and invitro models from the wide array of cell lines available at our Cell line Biorepository

Oncology research group is interested in establishing the long-term outcomes in women treated for breast cancer and the molecular correlates of these outcomes.We have been the recipient of two 10-year philanthropic grants in addition to other extramural grants that have enabled such long-term un-interrupted activity. We currently also have National and International grants supporting our work including the most prestigious Welcome-DBT intermediate fellowship.

We have a unique advantage of a full time pathologist, molecular biologists, bioinformaticians and bio statisticians working in the Research facility .With our current scientific and technical expertise, we are primed to undertake industry liaised collaborations for various projects such as drug screening, testing of compounds of therapeutic value on a range of in-vivo and in-vitro model systems and big data analysis.

Clinical Development and Medical Affairs

Qualified and experienced scientific writers

Clinical Trial and Studies covered are:

Safety study of the cosmetics/products
Efficacy study of the cosmetics / products

Service Offerings:

Project management for Phase II and III clinical studies for Consumer care and Nutrition products

Study types:

Clinical end point studies
Diagnostics/ Devices
Derma studies

Advantages of Clinical studies :

Services are backed by state-of-the-art equipment technology
Expert clinicians/highly qualified and senior Doctors/ Consultants. Friendly and warm environment.

Our Strengths:

Modern State of the art Equipment with Fully automated analyzers/equipment
Highly qualified/ Experienced staff
Providing all clinical and Diagnostic services under one roof Going for accreditation

The overview of the clinical trials procedure:

Test protocols in line / aligned with the international guidelines.
Scale of measurements developed in accordance with the Caucasian skin type, and are supported by our clear understanding of the Indian skin type.
Improvised and standardized testing techniques and protocols in line with regulations, contemporary research requirements, product formulation and adjuvant methods.
Ability to cater to the needs and requirements of our clients in India, with regards to 24/48 hrs occlusive patch test, HRIPT, open application tests and stinging test, among many others.

With a dedicated area for skin evaluation, grooming, dental evaluation, skin sensitivity evaluation and imaging.
Equipment & Specialized Instruments specifically used for derma products and include hydration, elasticity, melanin, erythema, TEWL, and Digital camera devices among others

Services in Clinical Studies

Dermatology and Cosmetology studies
Diet, Nutrition, Weight

All Specialty Consultation
Cosmetology Consultation